Effects of Myricetin on Liver Functions Prior 5-Flurouracil in Male Rats

Abstract

5-Fluorouracil (5-FU) belongs to the chemotherapy class of anti-metabolites(anti-pyrimidine) is widely-used as an anticancer drug to treat solid cancers,such as those of the colon, breast, rectum, and pancreas. However, its clinicalapplication is limited due to its gastrointestinal and hematological toxicity.Myricetin (3, 3, 4, 5, 5,7-hexahydroxyflavone) is a naturally-occurringflavanol found in fruits, vegetables, teas, and medicinal plants that hasantimicrobial, antiviral, anti-aging, and anti-diabetic activities. The goal of thisstudy was to evaluate the effect of two doses of myricetin on 5-flurouracil-induced hepatotoxicity in Wistar rats. Forty-two male Wistar rats were dividedinto six groups of seven rats each: Control (group 1) rats received distilled waterdaily for 20 days; group 2 rats were intraperitoneally (IP)-injected with a singletoxic dose (150 mg/kg) of 5-FU on day 20; groups 3 and 4 rats orally-receivedeither 25 or 50 mg/kg/day of myricetin, respectively, for 20 days. Group 5 and 6rats orally-received 25 or 50 mg/kg/day of myricetin, respectively, for 20 days,and were IP-injected with 5-FU on day 20. From the results obtained from thisstudy, it can be concluded that myricetin increases antioxidant levels andreduces liver inflammation, decreasing negative side-effects. The inclusion ofmyricetin with 5-FU resulted in positive histological changes that enhancedliver function.