Phytochemical And Hepatoprotective Activity Of Plant Extract Of Dalbergia Sissoo Seeds

Abstract

The current work aims to perform a photochemical analysis and a hepatoprotective activity study of various Dalbergia sissoo seed extracts. The Fabaceae family includes Dalbergia sissoo DC., which has ruminate medicinal properties. Aqueous, methanolic, and chloroform extractions were performed in succession to create the various plant extracts. After that, these extracts (AEDS, MEDS, and CEDS) were taken and subjected to a first phytochemical screening utilising accepted techniques. The hepatoprotective activity of the different extracts of Dalbergia sissoo was evaluated by using carbon tetrachloride induced liver damage in experimental rats. In hepatotoxicity induced animals, an oral dose of 200 mg/kg, of the aqueous, methanol and chloroform extracts of Dalbergia sissoo exhibited a compelling decrease in marker enzyme levels and increased levels of antioxidant enzymes. When tested animals were exposed to the above dosage of plant extracts, their levels of lipid peroxidase significantly decreased in response to liver damage generated by carbon tetrachloride. The greatest hepatoprotective efficacy was observed in the methanolic extract, which was also shown to be rich in phytochemical components. Our current study's results led us to the conclusion that Dalbergia sissoo DC's methanolic extract exhibited a strong antioxidant defence mechanism as well as hepatoprotective activities. Because of their antioxidant qualities, polyphenolic compounds may have hepatoprotective potential.