Anti-Epileptic Activity Of Casticin Phytoconstituent From Vitex Negundo On Validated Animal Model

Abstract

The objective of this research is to explore the potential antiepileptic effects of a methanolic extract of vitex negundo leaf on seizures in mice that were induced by lithium pilocarpine, maximum electroshock (MES), strychnine, picrotoxin, and pentylenetetrazole. Specifically, the study will focus on the effects of the extract on seizures caused by these substances. The extract was able to prevent convulsions that were brought on by MES, and it was also able to help normal medications work more effectively against convulsions that were brought on by other chemicals. In a manner that is dependent on the quantity of flavanoids that are present, the flavanoids that are contained in the methanolic extract of vitex negundo have the potential to disrupt the gabanergic process and block Na+ channels. Based on the preliminary data, it seems that the methanolic extract of vitex negundo has the potential to be used as a therapeutic resource for the treatment of epilepsy.